New target for universal influenza vaccine

 New research from scientists at the National Institutes of Health and La Jolla Institute for Allergy and Immunology (LJI) reveal a new target for universal influenza vaccines, which could protect against all types of influenza viruses without needing to be reformulated each year.

Scientists have identified a new target for developing a "universal" vaccine for influenza, which would be effective against different strains of the virus. The new findings, from researchers at Beth Israel Deaconess Medical Center (BIDMC), could lead to improved flu vaccines in the U.S. and other countries as well as inform strategies for developing universal vaccines for deadly viruses like Ebola and HIV.

Results show that core Fc,the fragment crystallizable region of the human antibody,can interact with SAα2-6Gal receptors on both human and avian cells,and is sufficient to trigger an immune response against a broad range of viruses.This finding provides key experimental support for the concept that antibodies to α2-6-linked carbohydrates could serve as a model for a universal influenzavaccine in the future.

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